Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative …

Both Gclc and Gclm are characteristic NRF2 target genes, which establish NRF2 as a regulator of glutathione, one of the most important antioxidants in the body.

Mar 4, 2025 · Over the last 30 years, NRF2 has evolved from being recognized as a transcription factor primarily involved in redox balance and detoxification to a well-appreciated master regulator of cellular...

Nov 26, 2025 · The Nrf2 pathway is a central biological process in health maintenance and the biology of aging, making it a major focus in longevity and disease prevention studies.

5 days ago · The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is best known for its regulation of the antioxidant response. However, its mediation of other pathways, including key …

Jan 21, 2026 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a central regulator of redox balance and innate antiviral defense. Because many viruses induce oxidative stress to support replication or …

Sep 29, 2021 · Nrf2 is present in an inactive state in the cytoplasm of cells. Its activation by internal or external stimuli, such as infections or pollution, leads to the transcription of more than 500 elements …

Explore the NRF2 pathway's critical role in oxidative stress, inflammation, and chronic disease. Learn how NRF2 activation supports neuroprotection, cardiovascular health, and metabolic function—with …

Jul 24, 2025 · Nrf2 (Nuclear factor erythroid 2-related factor 2) is a protein in the human body that plays a significant role in cellular defense. It acts as a sensor, detecting various forms of stress within cells …

Nrf2 is responsible for regulating an extensive panel of antioxidant enzymes involved in the detoxification and elimination of oxidative stress and has been extensively studied in the disease …